Carbenoxolone is a derivative of β-glycyrrhetinic acid (Item No. 11845), a major metabolite of glycyrrhizin, one of the main constituents of licorice. Similar to β-glycyrrhetinic acid and glycyrrhizin, carbenoxolone has been shown to exhibit anti-ulcerative and anti-inflammatory properties.{29513} Carbenoxolone inhibits 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; Item No. 10007815) conversion of cortisol to cortisone, which contributes to its potential to induce mineralocorticoid hypertension.{11854} It is also reported to inhibit 11β-HSD2 conversion of cortisone to cortisol resulting in improved cognitive and neuroprotective effects.{24097}
产品描述
A derivative of β-glycyrrhetinic acid a major metabolite of glycyrrhizin, one of the main constituents of licorice, with anti-ulcerative and anti-inflammatory properties; inhibits 11β-HSD1 conversion of cortisol to cortisone, which contributes to its potential to induce mineralocorticoid hypertension; also inhibits 11β-HSD2 conversion of cortisone to cortisol resulting in improved cognitive and neuroprotective effects
