Progesterone (Item No. 15876) is a steroid secreted by the corpus luteum and placenta. It is responsible for preparing the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Gestodene is a synthetic progesterone analog (i.e., a progestin) that is structurally related to testosterone (Item No. 15645). A USP-approved grade of gestodene is often formulated in combination with ethynyl estradiol (Item No. 10006486) and provided for use as an oral contraceptive.{12452,29377} Gestodene offers a pharmacokinetic advantage over the other progestins in that it is directly active (the others are prodrugs), has high bioavailability, and is androgenically neutral.{12452} Gestodene does not bind the estrogen receptor (ER); however, two of its A-ring metabolites can bind ER and possess weak estrogenic activity.{29378}
产品描述
A progesterone analog (i.e., a progestin); does not bind the ER, however, two of its A-ring metabolites can bind ER and possess weak estrogenic activity
