中文名称

IOX4

英文名字

IOX4

供应商

Cayman Chemical

产品货号

18181-25

产品报价

￥询价/25mg

产品说明书

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购买方式

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产品新闻

背景资料

Hypoxia inducible factors (HIFs) are regulated by the hydroxylation of prolyl residues in oxygen-dependent degradation domains, which leads to degradation by the proteasome.{21056,21057} HIF prolyl hydroxylation is catalyzed by prolyl hydroxylase domain enzymes (PHD1, 2, and 3), members of the Fe(II) and 2-oxoglutarate (2OG) oxygenase family. They require dioxygen as a co-substrate, thus acting as the hypoxia-sensing component of the HIF system. IOX4 is a potent inhibitor of PHD2 (IC50 = 1.6 nM).{29178} It displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases, including JMJD isoforms, FBXL11, JARID1C, BBOX1, FIH, and FTO. IOX4 is active in vivo, inhibiting prolyl hydroxylation and increasing HIF-1α levels in cells (IC50 values range from 5.6 to 11.7 µM) and inducing HIF-1α and HIF-2α expression in mice.{29178} The induction of HIF expression in mice occurs in the brain as well as in the liver, kidney, and heart, indicating that IOX4 penetrates the blood-brain barrier.{29178}

产品描述

A selective, potent inhibitor of PHD2 (IC50 = 1.6 nM); active in vivo, inhibiting prolyl hydroxylation and increasing HIF1α levels in cells (IC50 values range from 5.6 to 11.7 µM) and inducing HIF1α and HIF2α expression in mice; penetrates the blood-brain barrier to induce HIF expression in the brain

产品形式

晶体

保存建议

建议您在收到Cayman Chemical品牌的IOX4 (25 mg)产品后置于-20℃保存.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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