Dynorphin A is a heptadecapeptide released from the cleavage of prodynorphin and found widely distributed in the central nervous system, where it is implicated in antinociceptive functions.{29497,29499,29498} It acts as an opioid receptor agonist with nanomolar binding affinity to the three major isotypes κ, µ, and δ (Kis = 0.5-1 nM) and has also been shown to activate human ORL1, a novel opioid receptor-like receptor (Ki = 386 nM).{29543}
产品描述
A heptadecapeptide that acts as an endogenous opioid receptor agonist (Kis = 0.5-1 nM for κ, µ, and δ); has been implicated in antinociceptive functions
