Elacridar is a dual inhibitor of P-glycoprotein (MRP-1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2). It maximally inhibits P-glycoprotein in isolated human peripheral blood leukocytes at 200 nM.{29372} Elacridar blocks the activity of P-glycoprotein at the blood-brain barrier, altering the pharmacokinetics of certain drugs in the brain.{29371} This compound is effective against both human BCRP and the mouse homolog, Bcrp1.{29369,29370}
产品描述
A dual inhibitor of MRP-1 and BCRP; maximally inhibits MRP-1 in isolated human peripheral blood leukocytes at 200 nM; effective against both human BCRP and the mouse homolog, Bcrp1
