Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexol is a folate analog antimetabolite with antineoplastic activity.{29444,29446} At nanomolar conentrations, it inhibits GART preventing de novo purine synthesis, inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation.{29445}
产品描述
A folate analog antimetabolite that inhibits GART preventing de novo purine synthesis; inhibits DNA synthesis, arrests cells in the S phase of the cell cycle, and inhibits tumor cell proliferation
