The α chain of fibrinogen combines with the β and γ chains to form an insoluble fibrin matrix. Fibrin is a major component of blood clots, and also functions during wound repair by guiding cell migration during re-epithelialization. The modification of fibrinogen by citrullination can result in the production of anti-citrullinated auto antibodies (ACPAs). The presence of ACPAs against citrullinated fibrinogen is a common symptom of rheumatoid arthritis patients. The α chain of fibrinogen (isoform 2) is 69.8 kD and Cayman’s Fibrinogen Polyclonal Antibody (α chain) detects a band at approximately 70 kD.
应用类型
WB
免疫原
Peptide from the C-terminal region of human fibrinogen (α chain)
