中文名称

D-赤型-鞘氨醇-1-磷酸

英文名字

D-erythro-Sphingosine-1-phosphate

供应商

Matreya

产品货号

1803-5

产品报价

￥询价/5mg

产品说明书

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购买方式

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产品新闻

背景资料

D-erythro-Sphingosine-1-phosphate, the natural isomer, has important signaling functions both intra- and inter- cellularly and is present at low concentrations in cells. It can promote cellular division, regulate calcium mobilization and cell growth, and can either inhibit or promote apoptosis depending on the circumstances.1 In the metabolism of sphingosine-1-phosphate, sphingosine is first released from ceramides by the enzyme ceramidase and is then phosphorylated by sphingosine kinase. Sphingosine-1-phosphate can then be cleaved by the enzyme sphingosine-1-phosphate lyase to yield trans-2-hexadecenal, which can be further catabolized or reduced to sphingosine and this is the means by which sphingolipids are removed from cells.2 Unlike most other sphingolipids it does not form lipid rafts in membranes and is found in the low nanomolar range in cells. However, in plasma, it can reach a much higher concentration and is stored in relatively high concentrations in human platelets and erythrocytes. Sphingosine-1-phosphate exerts its extra-cellular effects by acting as a ligand for specific receptors. These ligand-receptor interactions are important for the growth of new blood vessels, vascular maturation, cardiac development and immunity, the inflammatory process, and for directed cell movement.3 Sphingosine-1-phosphate and its receptors may also be involved in regulating heart rate, blood flow in the coronary artery and blood pressure. It is an indicator for certain types of cancer, probably due to its role in cell division and proliferation and is abundant in malignant tissues. Therefore it is undergoing much scrutiny in the attempt to understand the development of these cancers and to investigate therapeutic interventions such as inhibiting its biosynthesis from ceramide. Sphingosine-1-phosphate is involved in regulating the proliferation, survival, differentiation and migration of many types of stem cells, especially in the development of the vascular and nervous systems.

产品描述

S-1-P

产品形式

该D-赤型-鞘氨醇-1-磷酸产品为固体形式

保存建议

对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明书。

其他

Matreya LLC是一家脂质生化公司，致力于开发和制造高质量的脂质和生物化学品。Matreya在化学合成以及天然产物提取和纯化方面经验丰富，生产出的产品具有最佳纯度。 Matreya产品线包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和维生素E异构体（生育酚和生育三烯酚）。专长是生产高纯度鞘氨醇、神经酰胺、硫酸酯、神经节苷脂、酶抑制剂、生育酚和生育三烯酚。是全球提供脂质产品最全的供应商之一。产品涉及生物化学、制药、微生物学、食品和农业等研究领域。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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