- 中文名称
吡拉西西布
- 英文名字
- Pilaralisib
- 供应商
- Cayman Chemical
- 产品货号
- 18011-5
- 产品报价
- ￥询价/5mg
- 产品说明书
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- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival. Pilaralisib is a methylbenzenesulfonamide derivative that reversibly inhibits class I PI3Ks (IC50s = 39, 36, 23, and 383 nM for p110α, -δ, -γ, and -β, respectively).{29152} It has been shown to abrogate Akt and S6 kinase phosphorylation, reduce cyclin D1 and retinoblastoma protein, and upregulate the CDK inhibitor p27, inhibiting cell proliferation.{29152} In HER2-overexpressing breast cancer cells, cotreatment with the HER2 inhibitors trastuzumab or lapatinib (Item No. 11493) are reported to sensitize tumor cells to the growth inhibitory effect of pilaralisib.{29153} This compound has been evaluated in clinical trials in patients with advanced solid tumors.{29154}
- 产品描述
- A reversible class I PI3K inhibitor (IC50s = 39, 36, 23, and 383 nM for p110α, -δ, -γ, and -β, respectively); inhibits HER2-overexpressing breast cancer cell proliferation
- 产品形式
- 晶体
- 保存建议
- 建议您在收到Cayman Chemical品牌的SAR245408; XL147 (CAS 934526-89-3) (5 mg)产品后置于-20℃保存.
- 其他
- Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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