Dyphylline is a xanthine derivative that acts as an A1 and A2 adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects.{29139,29142} It also moderately inhibits microsomal prostaglandin E synthase-1 with an IC50 value of 200 µM and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells.{29140,29141}
产品描述
A xanthine derivative that acts as an adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects; also inhibits mPGES-1 (IC50 = 200 µM) and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells
