Naringenin (Item No. 14173) is a citrus-derived flavonoid that inhibits cytochrome P450 (CYP) 3A4 activity in human liver microsomes (IC50s = 139-188 μM).{18074,22311} Naringin is a natural flavanone glycoside formed from naringenin and neohesperidose. It undergoes extensive metabolism in the liver, giving rise to naringenin and other bioactive metabolites that have anti-oxidant, anti-inflammatory, and anti-apoptotic effects.{29091} Naringin is a weak inhibitor of CYP3A4, providing 14% inhibition at 200 µM.{22311} It suppresses apoptosis in neurons and increases the expression of neurotrophic factor in dopaminergic neurons, providing neuroprotection.{29092}
产品描述
A natural flavanone glycoside formed from naringenin and neohesperidose; undergoes extensive metabolism in the liver, giving rise to naringenin and other bioactive metabolites that have anti-oxidant, anti-inflammatory, and anti-apoptotic effects
