Tryptanthrin is an alkaloid tryptophan derivative originally isolated from various plants and found to have antimicrobial actions. Among its many actions in cells, it inhibits both 5-lipoxygenase and cyclooxygenase-2 (IC50s = 600 and 64 nM, respectively).{29112,29109} Tryptanthrin suppresses angiogenesis in vivo and blocks signaling through VEGFR2 at the level of ERK1/2 signaling in vitro.{29110} It also prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity.{29111}
产品描述
An alkaloid originally found to have antimicrobial actions; both 5-LO and COX-2 (IC50s = 600 and 64 nM, respectively); suppresses angiogenesis, blocking signaling through VEGFR2 at the level of ERK1/2 signaling; prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity
