RTA 408 is a synthetic triterpenoid that binds Keap1 and attenuates the degradation of Nrf2 at concentrations ≤25 nM.{29061} In this way, it suppresses the generation of nitric oxide and pro-inflammatory cytokines in macrophages stimulated with IFN-γ.{29061} At higher concentrations, RTA 408 inhibits tumor cell growth (GI50 = 260 nM), blocks NF-κB signaling, and decreases levels of cyclin D1.{29061} Topical application of RTA 408 activates Nrf2 and provides cytoprotective effects.{29062,29063}
产品描述
Binds Keap1 and attenuates the degradation of Nrf2 at concentrations ≤25 nM, suppressing inflammatory signaling; inhibits tumor cell growth (GI50 = 260 nM), blocks NF-κB signaling, and decreases levels of cyclinD1; activates Nrf2 and provides cytoprotective effects when applied topically
