SCH 51344 is a pyrazolo-quinoline derivative that inhibits Ras-induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts.{28957} At 5-25 µM, it has been shown to dose-dependently block Ras/Rac-induced membrane ruffling in REF-52 fibroblasts with little effect on Ras-induced ERK and JNK kinase activity.{28958} SCH 51344 is also reported to be a potent inhibitor of human mutT homolog MTH1, a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (Kd = 49 nM).{28959}
产品描述
An inhibitor of Ras-induced malignant transformation that prevents anchorage-independent growth of oncogene transformed fibroblasts; blocks Ras/Rac-induced membrane ruffling in REF-52 fibroblasts (5-25 µM) with little effect on Ras-induced ERK and JNK kinase activity,,
