Elvitegravir is a quinolone antibiotic that inhibits the integrase of HIV-1 (IC50 = 7.2 nM).{29011} It blocks the integration of HIV-1 cDNA through the inhibition of DNA strand transfer.{29012} Elvitegravir is used in combination with a pharmacoenhancer and nucleoside/nucleotide reverse transcriptase inhibitors to block HIV-1 replication in vivo.{29009,29010}
产品描述
A quinolone antibiotic that inhibits the integrase of HIV-1 (IC50 = 7.2 nM); blocks the integration of HIV-1 cDNA through the inhibition of DNA strand transfer