Sivelestat is a potent and selective inhibitor of neutrophil elastase (IC50 = 44 nM).{29354} It is without effect on a panel of related proteases.{29354} Sivelestat is effective in vivo, blocking elastase-dependent acute lung injury induced by intratracheal administration of LPS.{29354,29356} Elastase inhibitors, including sivelestat, have clinical utility in protecting against direct or indirect lung injury, with or without concomitant sepsis.{29353,29355,23600}
产品描述
A potent and selective inhibitor of neutrophil elastase (IC50 = 44 nM); effective in vivo, blocking elastase-dependent acute lung injury
