Toceranib is a small molecule, multi-targeted receptor tyrosine kinase inhibitor that is structurally related to sunitinib (Item No. 13159).{17826} It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit.{17826} Moveover, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death.{17826} It is active in vivo and is commonly used against solid tumors in dogs.{28879,28880}
产品描述
A small molecule, multi-targeted receptor tyrosine kinase inhibitor; blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death; active in vivo and commonly used against solid tumors in dogs
