GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations.{27421} GPR84 is expressed in leukocytes and its expression is further induced by LPS.{27421,29190} 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM).{29190} It has insignificant actions at a panel of 69 other receptors, channels, or transporters.{29190} 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages.{29190} In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.{29190}
产品描述
A synthetic agonist for GPR84 (EC50 = 512 nM); promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages; drives the recruitment of leukocytes and raises serum levels of CXCL1 (GRO-α) in vivo
