Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling.{26503} In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer’s disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM.{28670} It demonstrates 10-fold selectivity for IDE over a panel of enzymes with reactive cysteine residues.{28670}
产品描述
A selective IDE inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM
