ML-299 is a dual inhibitor of the two mammalian forms of phospholipase D (PLD), PLD1 and PLD2 (IC50s = 6 and 20 nM, respectively).{28737} It dose-dependently decreases the invasive migration of U98-MG glioblastoma cells into matrigel.{28737} ML-299 penetrates the central nervous system and is functional in vivo when given intraperitoneally.{28738} As PLD1 and PLD2 have roles in cancer and viral infection, ML-299 has potential applications in oncology and virology.{28738}
产品描述
A dual inhibitor of the two mammalian forms of PLD, PLD1 and PLD2 (IC50s = 6 and 20 nM, respectively); penetrates the CNS and is functional in vivo when given intraperitoneally; has potential applications in oncology and virology
