Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.{28779,28780} It is nonphosphorylatable and selective for CaMKII over PKC, PKA and CaMKIV (IC50s > 10 μM).{28779,28780} This compound is a useful tool for studying the physiological roles of CaMKII.{28781}
产品描述
A selective CaMKII inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase
