The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC50 = 0.39 µM).{29266} In MCF7 cells, it blocks proliferation with an IC50 value of 1.25 µM.{29266}
产品描述
A cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC50 = 0.39 µM); blocks MCF7 cells proliferation with an IC50 value of 1.25 µM