Dibefurin, a fermentation metabolite of the fungal strain AB 1650I-759, inhibits the activity of calcineurin (IC50 = 44 µM), a calcium/calmodulin-dependent protein phosphatase involved in the activation of T lymphocytes.{28478,28477} In contrast to calcineurin inhibitors, cyclosporin A (Item No. 12088) or FK-506 (Item No. 10007965), dibefurin directly inhibits the enzyme and does not act through ternary immunophilin complexes.{28477}
产品描述
A direct inhibitor of calcineurin phosphatase activity (IC50 = 44 µM)