Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).{28698} Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.{28698} Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth.{28698} It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet.{28698,28695} Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage.{28694} Cytosporone B also has antibacterial properties.{28693,28696}
产品描述
A naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM); induces apoptosis in cancer cells and retards xenograft tumor growth; induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat/high cholesterol diet
产品形式
晶体
保存建议
建议您在收到Cayman Chemical品牌的Csn-B; Dothiorelone G (CAS 321661-62-5) (5 mg)产品后置于-20℃保存.
