Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. With roles in cell proliferation and differentiation, its expression increases during development and in pathological conditions such as cancer.{28470} Furthermore, the intracellular accumulation of ganglioside GD3 can contribute to mitochondrial damage, a crucial event during apoptosis.{5033} Ganglioside GD3 has become a target for therapeutic approaches to prevent malignant properties of tumor cells like melanoma.{28470,28471}
产品描述
A minor ganglioside with roles in cell proliferation and differentiation, whose expression increases during development and in pathological conditions such as cancer; targeted for therapeutic approaches to prevent malignant properties of tumor cells like melanoma
