p53-Binding protein 1 (53BP1) binds to dimethylated lysine 20 on histone 4 (H4K20me2) via tandem tudor domains on a 53BP1 homodimer.{28750} This interaction is an important part of the DNA damage response.{28750} UNC2170 is a micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains.{28751} It displays at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins.{28751} UNC2170 functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain.{28751}
产品描述
A micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains on a 53BP1 homodimer; functions as a 53BP1 antagonist in cellular lysates
