U-73122 (Item No. 70740) is an inhibitor of PLC-dependent processes, however, the mechanism of action remains unclear.{5296,3187,6007} The IC50 values for inhibition of platelet aggregation induced by collagen or thrombin are 0.6 and 5 µM, respectively.{3187} It also exhibits inhibitory activity against HIV-1 integrase with an IC50 value of 7 µM.{3607} U-73343 is a close structural analog of U-73122 that does not inhibit PLC, making it useful as a negative control for PLC inhibition.{5296}
产品描述
An inactive analog of U-73122; can be used as a negative control