Mirabegron is a β3-adrenergic receptor agonist (EC50 = 22.4 nM) that displays potent selectivity for β3 compared to the β1 and β2 receptor subtypes (EC50s ≥ 10 µM).{28306} It has been shown to relax rat and human bladder strips precontracted with carbamoylcholine (Item No. 14486) with EC50 values of 5.1 and 0.78 µM, respectively.{28306} Clinical trials have supported the efficacy of mirabegron in overactive bladder therapy.{28307}
产品描述
A β3-adrenergic receptor agonist (EC50 = 22.4 nM) that displays potent selectivity for β3 compared to the β1 and β2 receptor subtypes (EC50s ≥ 10 µM); relaxes rat and human bladder strips precontracted with carbamoylcholine (EC50s = 5.1 and 0.78 µM, respectively)
