The calpains are a family of calcium-dependent cysteine proteases, with calpain I (µ-calpain) requiring micromolar calcium and calpain II (m-calpain) requiring millimolar calcium. Calpain Inhibitor XI is a cell-permeable dipeptidyl α-ketoamide that acts as a reversible, and active-site inhibitor of calpain I and II (Kis = 140 nM and 41 nM, respectively).{23178} It weakly inhibits cathepsin B (Ki = 6.9 µM).{23178} Calpain Inhibitor XI has been shown to be neuroprotective following focal ischemia and to delay apoptosis in injured mouse spinal cord neurons.{10157,29726}
产品描述
A cell-permeable, reversible, and active-site inhibitor of calpain I and II (Kis = 140 nM and 41 nM, respectively); neuroprotective following focal ischemia and to delay apoptosis in injured mouse spinal cord neurons
