Furosemide is an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Ki = ~10 µM for each).{23244,28297} It is commonly used as a loop diuretic, blocking NKCC2 action on the apical membrane of the thick ascending limb of Henle epithelial cells.{28297} Furosemide also acts as an antagonist of GABAA receptors and as an inhibitor of carbonic anhydrase and organic anion transporter 1.{28298,23242,28296}
产品描述
An inhibitor of the NKCC cotransporters, NKCC1 and NKCC2 (Ki ~10 µM for each); commonly used as a loop diuretic
