VLX600 is a compound that shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 µM) with selectivity for malignant cells.{28502} It induces necrosis in non-proliferating quiescent core cells in multicellular spheroids (MCs) formed from HCT116 colon cancer cells.{28502} VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs.{28502} It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice.{28502}
产品描述
Shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 µM); induces necrosis in non-proliferating quiescent core cells in multicellular spheroids formed from HCT116 colon cancer cells; displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice
