Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery. It induces the expression of glutathione S-transferase and reduces chemical-induced carcinogenesis in mice.{28317} Sedanolide inhibits cyclooxygenases-1 and -2 at 250 pg/ml and blocks topoisomerase-I and-II activity at 100 µg/ml.{28315} It is mosquitocidal, nematicidal, and antifungal but shows no cytotoxicity against normal mammalian cells.{28314,28316}
产品描述
A natural phthalide that induces the expression of GST and reduces chemical-induced carcinogenesis in mice; inhibits COX-1 and -2 at 250 pg/ml and blocks topoisomerase-I and-II activity at 100 µg/ml
