Exchange proteins activated by cAMP (EPACs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2.{23361} 8-pCPT-2'-O-Me-Cyclic AMP is an 8-(4-chlorophenylthio) analog of cAMP that activates EPACs (AC50 = 1.8 µM).{28115} It is a super-activator of EPACs in that it dissociates GDP from Rap1 more strongly than the natural EPAC agonist, cAMP.{28115,28118} 8-pCPT-2'-O-Me-cAMP is strongly selective for EPAC over the cAMP-activated kinase PKA.{28118} It does not discriminate between EPAC1 and EPAC2 and is used extensively to elucidate the roles of these Rap GEFs in cell function.{23361,28116,28117,23348}
产品描述
An analog of cAMP that super-activates EPACs (AC50 = 1.8 µM), dissociating GDP from Rap1 more strongly than the natural EPAC agonist, cAMP; strongly selective for EPAC over PKA
