Dabigatran is a potent thrombin inhibitor (Ki = 4.5 nM).{28063,28064} It also inhibits trypsin (Ki = 50.3 nM), but only weakly inhibits other serine proteases.{28063,28064} Dabigatran has poor bioavailability after oral administration. However, dabigatran etexilate (Item No. 17131) is a double prodrug that has excellent oral bioavailability and undergoes in vivo hydrolytic cleavage to produce dabigatran.{28063,28064}
产品描述
A potent thrombin inhibitor (Ki = 4.5 nM); also inhibits trypsin (Ki = 50.3 nM), but only weakly inhibits other serine proteases; has poor bioavailability after oral administration
