Acid ceramidase inhibitor 17a is a benzoxazolone carboxamide that potently inhibits acid ceramidase (IC50 = 79 nM).{27811} This effect is persistent, as it inhibits acid ceramidase activity in cells for up to 24 hours. Acid ceramidase inhibitor 17a is extremely stable in buffers and plasma and shows good pharmacokinetics when administered intravenously or intraperitoneally in mice.{27811} It causes a significant reduction in acid ceramidase activity in multiple organs in mice, including brain, liver, heart, lungs, and kidney.{27811}
产品描述
A benzoxazolone carboxamide that potently inhibits acid ceramidase (IC50 = 79 nM); extremely stable in buffers and plasma and shows good pharmacokinetics when administered intravenously or intraperitoneally in mice, significantly reducing acid ceramidase activity in multiple organs
