Helenalin is a sesquiterpene lactone first isolated from various species of Arnica. It has anti-inflammatory effects, most notably by inhibiting gene expression mediated by NF-κB at doses from 1 to 20 µM.{27838,24738} Like other sesquiterpene lactones, helenalin can modify sulfhydryl groups of cysteine residues and it alkylates these groups on the p65 subunit of NF-κB.{27838} It also suppresses the proliferation of cancer cells through multiple mechanisms, including the prevention of signaling through NF-κB.{27836,20972,27837} Helenalin has antibacterial and anti-protozoal activities.{27839,27840}
产品描述
A sesquiterpene lactone with anti-inflammatory effects, most notably by inhibiting gene expression mediated by NF-κB at doses from 1 to 10 µM; suppresses the proliferation of cancer cells through multiple mechanisms; has antibacterial and anti-protozoal activities
