A cell-permeable prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor alpha (HIF-alpha) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1alpha; promotes cell survival under hypoxic conditions. DMOG posseses neuroprotective effect on NFG deprived cell cultures through preservation of glucose metabolism. DMOG also attenuates myocardial injury in a rabbit ischemia reperfusion model.Formula:C6H9NO5Solubility:DMSO (~100mM) or H2O (~100mM)Molecular Weight: ~175.14Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
