Rp-Cyclic AMPS (Rp-cAMPS) is a non-hydrolyzable phosphorothioate analog of cAMP.{26216} It is a competitive inhibitor of cAMP-dependent protein kinases I and II (IC50s = 12.5 and 4.5 µM, respectively).{27707,27705} Rp-cAMPS is not hydrolyzed by bovine heart cAMP phosphodiesterase but can be hydrolyzed by yeast phosphodiesterase.{27706} It is broadly used in research involving cAMP-dependent signaling in vitro and in vivo.{26216,26217,26218}
产品描述
A non-hydrolyzable phosphorothioate analog of cAMP that competitively inhibits cAMP-dependent protein kinases (PKA) I and II (IC50s = 12.5 and 4.5 µM, respectively); broadly used in research involving cAMP-dependent signaling in vitro and in vivo