Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir (Item No. 13874).{22168,24528} Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24520,24521} Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.{24528}
产品描述
A prodrug of the HIV reverse transcriptase and hepatitis B virus polymerase inhibitor, tenofovir; >100-fold greater anti-HIV activity than that of poorly bioavailable tenofovir in a T cell line and primary blood lymphocytes
