中文名称

N1-羟基-N3-（2-苯乙基）-1,3-苯二甲酰胺

英文名字

N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide

供应商

Cayman Chemical

产品货号

16919-5

产品报价

￥询价/5mg

产品说明书

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购买方式

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产品新闻

背景资料

HDACs are a family of proteins with diverse roles. HDAC6 is a class IIb histone that deacetylates cytoplasmic proteins, including tubulin, heat shock protein 90, and cortactin, and has roles in cell adhesion and motility.{26999} HDAC8, on the other hand, is a class I histone that primarily targets nuclear proteins, including histones and cohesins, and regulates gene expression.{17079,21527} BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively).{27579} It is at least 75-fold less effective against other HDAC isoforms.{27579} At 10 µM, BRD73954 treatment results in a robust increase in acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, 2, and 3, in HeLa cells.{27579}

产品描述

A small molecule inhibitor that potently and selectively inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively)

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的BRD73954 (5 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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