- 中文名称
15-keto Latanoprost (100 mg)
- 英文名字
- 15-keto Latanoprost, 9.alpha.,11.alpha.-dihydroxy-15-oxo-17-phenyl-18,19,2-trinor-prost-5Z-en-1-oic acid, isopropyl ester
- 供应商
- Cayman
- 产品货号
- 16816-100
- 产品报价
- ￥38640/100 mg
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Latanoprost is an F-series prostaglandin -PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto latanoprost. 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease -1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 ug/eye. 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 ug/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2.alpha. will produce this degree of miosis at a dose of less than 1 ug/eye. Products of .beta.-oxidation account for most of the metabolites of latanoprost recovered in plasma and urine. However, 15-keto latanoprost is a minor metabolite, and one which could be enhanced in situations where .beta.-oxidation is reduced.
- 产品描述
- A potential metabolite of latanoprost when administered to animals
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
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