Triptolide, a diterpenoid triepoxyde, a purified component of a traditional Chinese medicine, inhibits transcriptional activation of NF- kB and downregulates the expression of various NF- kB-regulated genes. Displays Immunosuppressive, anti-inflammatory, anti-angiogenic and antitumor activity. A combination of TRAIL and triptolide enhance apoptosis in cholangiocarcinoma cell lines.Solubility:DMSO (20mg/ml)Molecular Weight:~360.4DStorage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
