An isozyme-selective inhibitor of protein kinase Cb (PKCb). Inhibits both the PKCbI (IC₅₀=4.7 nM) and PKCbII (IC₅₀=5.9nm) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCbI and PKCbII over PKCa.Solubility:DMSO Molecular Weight:~505.01Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
