Physiologically active metabolite of the immunosuppressive drug leflunomide. Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-kB activation in a dose- and time-dependent manner. Also inhibits the activity of COX-2 in vitro and in vivo.Solubility:DMSOMolecular Weight:~270.21DStorage and Stability:Store at -20 °C. Protect from light.