Bialaphos is a natural non-selective phytotoxin produced by certain Streptomyces species. It is a pro-toxin, a tripeptide that is converted in vivo to the active agent phosphinothricin, which is a glutamine analog.{27463} L-Phosphinothricin inhibits glutamine synthetase (Ki = 6.1 µM), resulting in accumulation of ammonium and disruption of primary metabolism.{27463,27464} The bacterial bar gene encodes a phosphinothricin acetyltransferase, which confers resistance to phosphinothricin.{27244} Bialaphos is used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter.{27244}
产品描述
A natural non-selective phytotoxin that is converted in vivo to the active agent phosphinothricin, which inhibits glutamine synthetase (Ki = 6.1 µM); used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter
