Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is cleaved by serine proteases, resulting in self-activation of the receptor by a tethered ligand.{27549,27550} The ligand corresponds to residues 39-44 (SLIGRL in mouse PAR-2).{27549,27550} SLIGRL-NH2 is a recombinant peptide that activates PAR2 (EC50 = ~5 µM), without requiring receptor cleavage.{27549,27550} This peptide does not activate PAR1. Through its effects on PAR2, SLIGRL-NH2 stimulates gastric and intestinal smooth muscle contraction and induces thermal hyperalgesia in mice.{27547,27548} SLIGRL-NH2 is used to explore signaling through PAR2 in cells and in animals.{27551,27546}
产品描述
A recombinant peptide that activates PAR-2 (EC50= ~5 µM), without requiring receptor cleavage; used to explore signaling through PAR2 in cells and in animals
