中文名称

GSK-J5 Hydrochloride

英文名字

GSK-J5 Hydrochloride

供应商

USBiological

产品货号

164333

产品报价

￥1/5mg

产品说明书

点击查看

购买方式

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产品新闻

背景资料

USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述

GSK-J5 Hydrochloride is a selective jumonji H3K27 demethylase inhibitor that modulates the proinflammatory macrophage response. The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.1,2 GSK-J4 (Item No. 12073) is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1 (Item No. 12054), an inhibitor of JMJD3. GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base.3 However, the free base is a weak inhibitor of JMJD3 (IC50 > 100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition.3Storage and Stability:For long term storage, we suggest that GSK-J5 (hydrochloride) be stored as supplied at -20°C. It should be stable for at least two years.GSK-J5 (hydrochloride) is supplied as a crystalline solid. A stock solution may be made by dissolving the GSK-J5 (hydrochloride) in the solvent of choice. GSK-J5 (hydrochloride) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of GSK-J5 (hydrochloride) in ethanol is approximately 20 mg/ml and approximately 30 mg/ml in DMSO and DMF.GSK-J5 (hydrochloride) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, GSK- J5 (hydrochloride) should first be dissolved in DMF and then diluted with the aqueous buffer of choice. GSK-J5 (hydrochloride) has a solubility of approximately 0.1 mg/ml in a 1:7 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

产品形式

艾美捷向您提供的GSK-J5 Hydrochloride产品形式查看产品说明书，建议按照产品说明书进行应用操作。

保存建议

接收到GSK-J5 Hydrochloride产品后，置于室温/4°C温度下保存。

其他

Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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