中文名称

2-HG | 2-羟基戊二酸；2-羟基戊二酸二钠盐

英文名字

2-HG|2-Hydroxyglutaric Acid; 2-hydroxy-pentanedioic acid, disodium salt

供应商

Cayman Chemical

产品货号

16374-25

产品报价

￥询价/25mg

产品说明书

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购买方式

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产品新闻

背景资料

α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenases 1 and 2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769}

产品描述

An α-hydroxy acid, overproduced in 2-hydroxyglutaric aciduria; mutations in IDH1 and IDH2 cause these enzymes to convert isocitrate to 2-hydroxyglutarate; competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的α-Hydroxyglutaric Acid (sodium salt) (25 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

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