中文名称

VprBP抑制剂；2-（5,6,7,8-四氢[1]苯并噻吩并[2,3-d]嘧啶-4-基）hydr 1H-吲哚-3-羧醛

英文名字

VprBP Inhibitor; 2-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone 1H-indole-3-carboxaldehyde

供应商

Cayman Chemical

产品货号

16364-5

产品报价

￥已停产

产品说明书

点击查看

购买方式

银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868

产品新闻

背景资料

Virus protein R (Vpr) is a virion-associated protein expressed by lentiviruses, including HIV-1 and -2. It causes cell cycle arrest in infected cells by binding the mammalian Vpr-binding protein (VprBP) on the DDB1/CUL4 ubiquitin ligase complex.{27569,27568} VprBP, also known as DDB1/CUL4-associated factor 1, acts as an adaptor protein but may also have other roles as part of the complex.{27570} B32B3 is a cell-permeable, ATP-competitive inhibitor of VprBP that blocks phosphorylation of histone 2A at Thr120 in DU-145 human prostate cancer cells (IC50 = 500 nM).{26488} It exhibits over 100-fold selectivity for VprBP against a panel of 33 other protein kinases.{26488} B32B3 strongly suppresses the proliferation of DU-145 cells, which overexpress VprBP, but not MCL normal human prostate cells, which have low levels of VprBP expression.{26488} At 5 mg/kg twice a week over three weeks, B32B3 inhibits the growth of DU-145 xenograft tumors in mice by 70-75%.{26488}

产品描述

A cell-permeable, ATP-competitive inhibitor of VprBP that blocks phosphorylation of histone 2A at Thr120 in DU-145 human prostate cancer cells (IC50 = 500 nM); strongly suppresses the proliferation of DU-145 cells, which overexpress VprBP, both in vitro and in xenograft tumors in mice

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的B32B3 (5 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

分享到：