The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers.{26669} PNU 74654 binds to β-catenin (KD = 450 nM), inhibiting its interaction with the transcription factor T-cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway.{26667} Treatment of human adrenocortical cell lines with PNU 74654 significantly reduced expression of several Tcf/β-catenin target genes.{26670}
产品描述
Binds to β-catenin (KD = 450 nM), inhibiting its interaction with the transcription factor T-cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway